Biochemist India: Career

225 Doctors across disciplines @ GTB Hospital

Company: Guru Teg Bahadur Hospital

Positions: Senior Resident - 117
Junior Resident - 138

Senior Resident
Department	Total no. of post	Date & Time of Interview
Dermatology	1	October 11, 2011 at 2 pm
ENT	1	October 11, 2011 at 2 pm
Ophthalmology	1	October 11, 2011 at 2 pm
Anaesthesia	32	October 12, 2011 at 2 pm
Burns & Plastic	6	October 12, 2011 at 2 pm
Dental	1	October 12, 2011 at 2 pm
Surgery	13	October 13, 2011 at 2 pm
Pathology	6	October 13, 2011 at 2 pm
Microbiology	3	October 13, 2011 at 2 pm
Medicine	10	October 14, 2011 at 2 pm
Neurosurgery	9	October 14, 2011 at 2 pm
Neurology	5	October 14, 2011 at 2 pm
Obst. & Gynae	6	October 17, 2011 at 2 pm
Biochemistry	1	October 17, 2011 at 2 pm
Paediatrics	8	October 17, 2011 at 2 pm
Orthopedics	5	October 18, 2011 at 2 pm
Radiology	10	October 18, 2011 at 2 pm
Psychiatry	1	October 18, 2011 at 2 pm
Total	117	October 18, 2011 at 2 pm
Junior Resident
Medical (MBBS)	138	October 19 & 20, 2011 at 12 pm

Note: No TA/DA will be paid for the interview

Eligibility:

Senior Resident

Candidate should have a Post Graduate degree or Diploma with two years experience.
He should be registered with Delhi Medical Council/Delhi Dental Council
He should be at least 40 years of age. (Relaxable for reserved category as per Government rule)

Junior Resident

Candidate should have MBBS degree from a recognized university.
He should be registered with Delhi Medical Council.
He should be at least 40 years of age. (Relaxable for reserved category as per Government rule)

Salary: Senior Residents - Between Rs.15, 600 and Rs.39, 100 plus grade pay Rs.6, 600 and other allowances as admissible under rules.
Junior Residents - Between Rs.15, 600 and Rs.39, 100 plus grade pay Rs.5, 400 and other allowances as admissible under rules.

How to apply: Submit application form along with a demand draft of Rs 500 as application fee in Room No. 331, 3rd floor, Admission Block, GTB Hospital.

DEMAND DRAFT should be drawn in favour of “Medical Superintendent” G.T.B. Hospital on or after 17 September 2011 as application fee. (No fee for reserved candidates.)

Tenure: Senior Residents are appointed for maximum 3 years with initial appointment for 1 year while Junior Residents are appointed for maximum 1 years with initial appointment for 6 months.

Application Deadline: 03 October 2011 till 4 pm

Address:
Room No. 331
3rd floor, Admission Block
GTB Hospital
Dilshad Garden, Delhi-110095

Website: http://delhi.gov.in/wps/wcm/connect/doit_gtbh/GTBH/Home

Lipid of the week : Sphingomyelin

Not merely membrane building blocks, sphingomyelin species carry out important signaling roles as precursor molecules and by providing localized platforms.

Sphingomyelin species comprise a ceramide unit and a phosphorylcholine or phosphoethanolamine polar headgroup. Typically, sphingosine is the long-chain base component of ceramide, although other long-chain bases can be present; differences in the sphingoid base and the fatty acid components (which are very-long-chain saturated and monounsaturated) confer great variability on the composition of sphingomyelins¹.

As a major constituent of cell membranes, sphingomyelin is found at particularly high concentrations in the membranes of nerve cells (in the myelin sheaths) and red blood cells. It was previously thought to have a purely structural role, similar to the function of phosphatidylcholine, through intermolecular interactions mediated by the 2-amide group, the 3-hydroxy group and the 4,5-trans double bond of the sphingoid base. However, it is now appreciated that sphingomyelin has a high affinity for cholesterol and that these two lipids pack tightly into liquid-ordered domains among a liquid-disordered phase to form lipid rafts¹². These membrane microdomains are thought to function as signaling platforms that regulate the localization and interactions of proteins. But sphingomyelin does not just influence signaling as a component of lipid rafts — it is also a precursor to ceramides and other sphingolipid metabolites that comprise the sphingomyelin cycle or sphingolipid network.

Sphingomyelin biosynthesis begins in the Golgi but continues in the plasma membrane. Sphingomyelin synthase catalyzes the transfer of phosphorylcholine from phosphatidylcholine to ceramide. The consequent decrease in ceramide levels is accompanied by an increase in the levels of sphingomyelin and the release of the well-known signaling molecule diacylglycerol. Alternatively, ceramide can also first be converted to ethanolamine phosphorylceramide through the transfer of the head group from phosphatidylethanolamine followed by sequential methylation of the ethanolamine moiety to a choline group, although whether this pathway is physiologically relevant is unknown¹.

Conversely, sphingomyelin can be metabolized to ceramide (and further, to other biologically active sphingolipids such as sphingosine and sphingosine-1-phosphate) by sphingomyelinases. The function of ceramide as a proapoptotic molecule is well known, although the exact mechanism through which this lipid induces cell death is not fully understood. By contrast, a decrease in ceramide levels accompanies the accumulation of sphingomyelin in cells of the brain, spleen and liver that occurs as a consequence of a deficiency in sphingomyelinase in Niemann–Pick disease types A and B¹. Notably, levels of cholesterol are also elevated in Niemann–Pick disease, which is consistent with reports suggesting that the metabolism, as well as the distribution, of these two lipids is linked, which has clear implications for several other diseases.

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